PBISC-Diffusion
Noise → Cells → Genes
Architecture · Figure 1
From bulk to cells
Pseudobulk → conditioned denoiser ↻ → generated cells
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01 / Cell maps
4,096 cells
Generated · 4,096Ground truth · 4,362PBMC5 + Other
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Recording & downloads
PCA · xₜ / UMAP · x̂₀ · Fixed axes
02 / Noise → Expression
One cell
Monocyte · 1 cell2,980 genesGround truth · Nearest single cell
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Recording & downloads
One tile = one gene · Endpoint-matched comparison
03 / Donor-level DEG
SLE vs HC
HC · 12 donorsSLE · 30 donorsIFNα · 61 genes
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Recording & downloads
63,000 generated cells · One dot = one gene
Methods & data
Recording metadata · Statistics · Downloads
Disease contrast · SLE vs HCIFNα set · 61 / 97 genes measured≥20 cells / donor / type · ≥5 donors / groupOther · Insufficient donors